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Presently, the plethora of identified NRF2 activators is of electrophilic nature and targets the reactive cysteine residues of KEAP1

This is unusual for such a rare condition

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Lilly has another candidate further ahead in development outside China that is taking up more of its R&D investment, namely retatrutide, a triple-acting agent that targets GLP-1, GIP, and glucagon in one molecule and is in several phase 3 trials across weight loss, diabetes, obstructive sleep apnoea, osteoarthritis, and chronic lower back pain, as well as for reducing the risk of cardiovascular and kidney complications in people with obesity

1,8-cineole ameliorates diabetic retinopathy by inhibiting retinal pigment epithelium ferroptosis via ppar-/txnip pathways