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By slowing gastric emptying and signaling fullness to the brain, Semaglutide helps men naturally reduce caloric intake without extreme dieting

There is variability across drugs [169,170,171,172]

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44 Semaglutide in Obese or Overweight Patients without Type 2 Diabetes Xie et al performed a systematic review of studies conducted in populations with OAO, but without T2DM, and indicated that semaglutide 2.4 mg had a significant advantage in decreasing body mass and HbA1c level, but the incidence of total AEs was also the highest and could cause hypoglycemia

Another aspect of the present invention relates to an anion exchange chromatography process for purifying a GLP-1 peptide from a mixture comprising said peptide and related impurities, comprising the step of: separating said GLP-1 peptide and said related impurities of said mixture by elution in a solution consisting essentially of an organic modifier, water, optionally a salt component, and optionally a buffer, with a linear or step gradient or isocratically in salt component and/or with a linear or step pH-gradient or at a constant pH-value, wherein the pH-gradient or pH-value should be in the range where said peptide has a negative local or overall net charge different from the local or overall negative net charge of said related impurities so as to remove said related impurities