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Such buffering could for example be mediated by activation of the Nrf2-Keap1-ARE pathway, which has been shown to be increased after polyphenol supplementation which in turn induces the expression of phase II detoxifying enzymes, responsible for reducing endogenous toxic metabolites [65]
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For this, we need to look at Ozempic, which was approved for type 2-diabetes in 2017
Several meta-analyses have confirmed these ergogenic effects of creatine supplementation [3, 4, 5, 6]
