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The protection of cells against oxidative stress
In a body composition substudy in people with type 2 diabetes and obesity (PMID: 40609566), retatrutide produced a lean mass loss of about 38% of total weight loss, which falls within the 2040% range reported for other GLP1based therapies such as semaglutide and tirzepatide (see PMID: 40609564
THE SCIENCE How GLP-1 Medications Work GLP-1 receptor agonists correct the biological signaling that drives hunger and fat storage
Clinical impact: Patients frequently report decreased interest in alcohol and sugar-heavy foods
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