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171 In recent years, a 5-LOX inhibitor upstream of LTB4 has been under development for bronchial asthma, but current 5-LOX inhibitors have problems such as lack of selectivity, structureactivity relationships, methaemoglobin formation, and poor efficiency and oral availability
Chen A, Chen Z, Xia Y, Lu D, Yang X, Sun A, Zou Y, Qian J, Ge J
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