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Thyroid concerns: L-carnitine may counteract thyroid hormone activity at the tissue level, which is relevant for individuals with hypothyroidism or those on thyroid medication
TRIUMPH-3 didnt answer this and was never going to
How much this role vs non-transmission-related functions of Agm mediate protection in age-related dementias is less clear, but a supporting role for Agm/Glu co-transmission is consistent with Agm protection against excitotoxicity in AD models (Zhu et al., 2003)
This reference is relevant when GLP-1 appetite reduction raises iron, B12 or folate questions
486,487,488 Notably, filgotinib has good oral availability, reaching maximum plasma concentrations at 13 h and plasma steady-state concentrations on day 2, making it a promising biologic agent for the treatment of UC
