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Studies have shown that metformin is superior to placebo in lowering testosterone levels compared to placebo or lifestyle interventions as well as lowering Free Androgen Index (FAI)
The mesolimbic dopamine system your brains core "wanting" circuit evolved to drive pursuit of survival rewards: food, mates, connection, status
Philos Trans R Soc B
however, clinically viable GLP-1 receptor agonists did not emerge until advances in peptide stabilization, delivery, and dosing strategies were achieved (Campbell and Drucker, 2013
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