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Adrenal or thyroid disease: DSIP can interact with HPA-axis signaling

For chronic weight management, both trizepatide (Zepbound) and semaglutide 2.4 mg (Wegovy) are indicated for adults with a BMI 30 or a BMI 27 with at least one weight-related condition (such as hypertension, dyslipidemia, type 2 diabetes, sleep apnea, or cardiovascular disease)

Given the heterogeneity in study design, populations, intervention duration, and clinical endpoints, findings were interpreted with careful consideration of variability across the evidence base