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While GLP1 receptor agonists have long been recognized for their glucose-lowering and weight-loss effects, they now offer potential for improving liver outcomes, especially in individuals with metabolic dysfunction-associated steatotic liver disease (MASLD) or its more advanced form, metabolic dysfunction-associated steatohepatitis (MASH)
This can occur through mechanisms such as slowing carbohydrate absorption, improving insulin sensitivity, interacting with other satiety hormones or via the microbiome
Medina PJ, Sipols JM, George JN (2001) Drug-associated thrombotic thrombocytopenic purpura-hemolytic uremic syndrome
The retatrutide versus tirzepatide comparison shows meaningful advantages for this next-generation compound