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GLP-1 medications are started at a low dose and titrated upward gradually over weeks to months
Glucagon receptor agonism increases: Basal metabolic rate Thermogenesis (heat production from brown adipose tissue) Hepatic fat oxidation Fatty acid oxidation in skeletal muscle The key insight is that when glucagon receptor agonism is combined with GLP-1R agonism (which counters glucagon's glucose-raising effects), the net glycaemic outcome remains favourable while the metabolic-rate and fat-oxidation benefits of glucagon are preserved
It is based on this amazing function that L-carnitine has been termed as a very effective solution in weight loss and fat burning
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