Among the antioxidants, it is described that ascorbic acid is depleted first when the body is under stress, followed by glutathione and vitamin E, leaving melatonin as the last line of defense against oxidative damage. (4) Since the melatonin is sacrificed and does not participate in redox cycling after scavenging free radicals, not only does melatonin not consume the basic cellular reductive force, glutathione, but it also preserves or even increases the content of glutathione in tissues (1) In one cell study, melatonin and vitamin C combined showed a more significant reduction in reactive oxygen species production (5)
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Understanding the underlying causes and addressing them holistically through lifestyle changes, dietary adjustments, and appropriate medical treatments can significantly improve the situation and provide relief from the relentless itching
Now, that's not to say, I definitely have patients who have found that semaglutide, which is the Ozempic, Wegovy equivalent, I do have patients who found that, found that better, interestingly