Data collection and clinical laboratory testing Demographic characteristics, including age, sex, body mass index (BMI), and use of lipid-lowering therapy, were recorded for each participant
Methods Protocol and registration The present systematic review and meta-analysis was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to ensure methodological rigor and transparency
Neurochem Int 119:178183 Hirsch EC, Hunot S (2009) Neuroinflammation in Parkinsons disease: A target for neuroprotection
Insulin resistance plays an important role in the pathophysiology of comorbid T2DM and depression and can be a trigger for dysregulation of insulin- and GLP-1-mediated signaling (both central and peripheral), neuroendocrine disorders (hypothalamicpituitaryadrenal system dysfunction and monoaminergic neurotransmission disorders), chronic low-intensity inflammation, oxidative stress, and disorders of the microbiota-gut-brain system, reducing the level of neurotrophic factors in the brain and changing synaptic plasticity
This once-weekly injectable medication is FDA-approved for weight management under the name Wegovy and for diabetes management under the name Ozempic