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Naltrexone is the generic name of the medication, while Vivitrol is a brand-name, extended-release version

During perimenopause and menopause, lower estrogen levels can increase insulin resistance, abdominal fat distribution, appetite changes, sleep disruption, and loss of lean muscle mass

Tirzepatide can be combined with insulin, but insulin doses typically require reduction to prevent dangerously low blood sugar

P values were calculated using a two-tailed Students t-test ( g ) one-way ANOVA ( b, d, e, i )