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After 12 weeks of treatment at 2 mg/kg/day (maximum 50 mg/day), verbal communication improved significantly more in the folinic acid group than in the placebo group, with a Cohens d effect size of 0.70 (medium-to-large) overall and 0.91 (large) in the FRAA-positive subgroup [3]

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doi: 10.1016/j.intimp.2022.109121 83

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Balancing these dynamics involves maintaining efficient supply chains and skilled personnel, which can impact costs

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2.1 Autism spectrum disorder Autism spectrum disorder (ASD) is a complex and heterogeneous neurodevelopmental disorder characterized by deficits in social communication and restricted, repetitive behaviors (27)

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10.2147/OPTH.S372114 261

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