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Vitamin B12 Medicine Interactions Chloramphenicol: bacteriostatic antibiotic can interfere with red blood cell response to supplemental Vit B12 Proton pump inhibitors: omeprazole and lansoprazole, etc., slow gastric acid release and may interfere with VIt B12 absorption from food H2-receptor antagonists: cimetidine, famotidine and ranitidine slow the release of hydrochloric acid into the stomach and interfere with Vitamin B12 absorption from food Metformin: might reduce absorption of Vitamin B12 due to altered intestinal motility, increased bacterial overgrowth, etc

They are complex biologic drugs, not simple pills, and their manufacturing process is intricate

Mancuso C, Bates TE, Butterfield DA, Calafato S, Cornelius C, De Lorenzo A, Dinkova Kostova AT, Calabrese V: Natural antioxidants in Alzheimer's disease

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in 1998 as the first selective growth hormone secretagogue