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These are uncommon at standard therapeutic doses and typically indicate the dose needs adjustment
Three principal amylin receptor subtypes exist [13] : AMY1 Receptor CTR + RAMP1 Primary receptor in area postrema (brainstem satiety center) [14] AMY2 Receptor CTR + RAMP2 Expressed in cardiovascular tissues and central nervous system [14] AMY3 Receptor CTR + RAMP3 Found in peripheral tissues including gastrointestinal tract [14] Cagrilintide binds to and activates these receptors with high affinity, triggering intracellular signaling cascades involving cyclic AMP (cAMP) and calcium mobilization [4]
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In a rat moderate contusive SCI model, subcutaneous administration of exenatide immediately post-injury and again at 7 days significantly improved hindlimb motor function without inducing hypoglycemia [66]
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