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Sodium handling also shifts on semaglutide because the medication influences aldosterone signaling, a hormone that regulates salt balance

Without medical supervision, many people dont know how to manage this symptom and may stop eating or hydrating properly, leading to malnutrition or severe dehydration

Some effects occur within minutes, such as blood glucose and insulin concentrations, while others, such as effects on synaptic density, muscle mass, or bone density, may take months

The absolute risk difference was an additional 27 (range 17-38) events per 100,000 patients per year

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