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Arch Med Sci DOI: 16
Lead series optimization Our goal was to enhance interactions of the small-molecule agonists with the GLP-1R through lowering the energy barrier to achieve the receptor-bound agonist conformation, and by adjusting polar substituents, with minimal increases in molecular weight
Energy-based work (Morpheus 8, Aerolase): 90 days for final remodeling
65 Conclusion GLP-1 RAs have become an important therapeutic option for patients with HFpEF, particularly those with comorbid T2D or obesity
2010 Jun 30
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