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Similarly, metformin administration commonly induces gastrointestinal disturbances, manifesting as diarrhea, abdominal distension, and nausea 12 , with potentially severe complications including lactic acidosis in rare instances 13

Importantly, there was no consistent signal for increased disease flares or therapy escalation. Ten studies reported safety outcomes

10.1097/sla.0b013e3181ae32e3 Ann

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However, new evidence has been forthcoming in recent years to suggest that human food intake is also controlled by other areas in the central nervous system, such as subcortical and cortical areas