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The elevated ROS level can activate specific redox-sensitive transcription factors (TFs) such as OxyR, PerR, OhrR, and SoxRS, which regulate detoxification genes by binding to their promoter regions and boosting enzyme synthesis
While your body does produce its own glutathione, factors of modern living such as stress, poor diet, lack of exercise and environmental toxins could lead to a deficiency
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The prevalence of melasma can be varied from 1% in the normal population to 50% in the high-risk population
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