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These effects include the reduction of inflammation and oxidative stress, vasodilation, decreased arterial stiffness, and a reduction in myocardial fibrosiskey factors in the pathophysiology of HFpEF
In CD8+ T cells, an MFN2-SERCA2 axis supports ER-mitochondria calcium homeostasis and mitochondrial metabolic competence, and disruption of this module compromises effector function and antitumor immunity, while reinforcement improves therapeutic efficacy, positioning ER-mitochondria interfaces as regulatory hubs that connect chronic stimulation to durable dysfunction (50)
Tambin se estudi si la ingestin de carnitina por va oral (6 g/d durante 14 das) cambia la concentracin de carnitina en el msculo en los humanos no obesos saludables o promueve la prdida de peso, con resultados negativos (Brass y col, 1994, Clin Pharmacol Ther 55: 681-92)
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