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Thus, disturbances in mitochondrial ICS biosynthesis could contribute to failures in the supply of energy (which might result in cell death) or to cancer, since genomic instability is considered as a hallmark of cancer and a driver of neoplastic transformation processes

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Research continues into its effects on hepatic fat, lipid profiles, and insulin sensitivity

Gastrointestinal side effects may be serious enough to force patients to stop treatment, thus limiting the effectiveness of these medications [7]

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