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It should be noted that recent studies have shown convergence between these two pathways such that AMPK activation is an upstream event of the NRF2-mediated antioxidant response 53

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Previously, we have shown that chemogenetic activation of GIPR-expressing cells in either the hypothalamus or the hindbrain supresses food intake 7,8 , and GIPR-expression in oligodendrocytes has recently been linked to enhanced access of co-administered GLP-1R agonists 23