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Collectively, these recent contributions argue that future GSH-centric redox sensing and nanomedical approaches should (i) incorporate organelle targeting (especially mitochondria) to exploit subcellular redox heterogeneity, (ii) embed analyte-responsive activation into both therapeutic and imaging components, (iii) combine biochemical sensing with optical or thermal engineering for spatiotemporal control, and (iv) favor clinically translatable carriers (e.g., PLGA) for delivery

SARS-CoV-2 invades cells by binding to ACE2, which leads to downregulation of ACE2 and feedback increased Ang II in the circulation, thus triggering NOX activation, resulting in oxidative stress and inflammation (Hikmet et al., 2020)

Jamil W, Svensson , Josefson A, Lindberg M, von Kobyletzki L

In a small double-blind, randomized clinical trial on 17 patients with cataracts, supplementation with lutein (15 mg, 3 times weekly for up to 2 years) was associated with improved visual acuity (Olmedilla 2003)

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