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PMID: 27411008

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Patients with established hypertension should have blood pressure measured at baseline and at each dose escalation (typically every 4 weeks during titration), then every 36 months once stabilised

[2] [3] The tiredness experienced by some patients likely reflects both direct medication effects and indirect consequences of the medication's therapeutic actions on appetite, food intake, and metabolism

Unlike approaches based on statistically significant differences between exposed and unexposed groups, which may conflate statistical association with causal structure, DAGs provide a formal framework to encode prior knowledge about causal relationships and to identify the minimal sufficient set of variables required for adjustment