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GLP-1 modulates actin polymerization, improving insulin sensitivity and glucose-stimulated insulin secretion Chronic hyperglycemia, or glucotoxicity, causes pancreatic cell dysfunction, diminished glucose-stimulated insulin secretion, and the production of long actin stress fibers 6,7
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Tirzepatide should be used with caution in patients with a history of pancreatitis, as GLP-1 receptor agonists have been associated with acute pancreatitis in postmarketing reports
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