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Neurological symptoms such as numbness, tingling in the hands or feet, muscle weakness, balance problems, or difficulty walking can occur

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The Endocrine Society's 2023 clinical practice guidelines on obesity pharmacotherapy note that "the absence of safety data in humans should not be conflated with a safety guarantee, particularly when preclinical mechanisms suggest CNS activity" [11]

Researchers continue to investigate these mechanisms as part of broader studies examining regenerative biology and cellular resilience

Last reviewed: November 16, 2025 CDC recommends waiting a minimum of 8 weeks (2 months) since the last 20242025 Formula COVID-19 vaccine to receive an age-appropriate 20252026 Formula COVID-19 vaccine, if using Comirnaty (Pfizer-BioNTech), Nuvaxovid (Sanofi-Novavax), or Spikevax (Moderna)