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This can increase the risk for cardiovascular disease, cancer, cognitive decline and bone fractures

4.3 Angiogenesis and vascular remodeling A hallmark of the hypoxic TME is the induction of angiogenesis, a process critical for supplying oxygen and nutrients to rapidly proliferating tumor cells (165)

Interestingly, adult mice with modest isolated elevations in GH and IGF-1 levels have greater lean mass, improved lipid oxidation and glucose clearance 38 , while specific, temporal reductions in GH and IGF-1 in adults have been linked to deleterious metabolic effects, including impaired hepatic insulin action 38 , and reduced -cell mass and function 39

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