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Ultimately, both GL and GA and their metabolites are primarily eliminated via bile and feces, with only a small fraction excreted in urine (Figure 2) (Chen et al., 2020)

Older people and people with digestive tract conditions are most at-risk for developing vitamin B12 deficiencies

doi:10.1056/NEJMc1313942

In addition, inhibitors of the enzyme glutaminase (GLS) that converts glutamine to glutamate, which is subsequently transformed to GSH via the glutamatecysteine ligase complex, efficiently induce cancer cell death through dysregulation of their antioxidant system 72