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A gap over 90 days between prescription fills marked the end of treatment, to account for immortal time bias [23]
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Early clinical trial data also suggest improvements in metabolic health markers, though the precise contribution of each receptor pathway including any effects on insulin sensitivity remains under investigation and should be interpreted in the context of early-phase findings rather than established fact
10.1016/j.ymgme.2015.10.005 Mol
Similarly, with 4.5 g/d there was a significant reduction in net lactate accumulation per unit power acutely - with like reductions also observed after 28 d at 1.5 g/d, but not but not after 28 d at 4.5 g/d
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