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Bulletin of Experimental Biology and Medicine (2021) 8

To overcome the barriers and to improve the adherence, oral GLP-1 RAs were needed, but oral protein-based drug absorption is limited because of degradation in the stomach due to low pH, proteolytic enzyme activity, and limited permeability across the gastrointestinal (GI) epithelium

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A separate analysis of patients with both obesity and a prior AUD diagnosis showed even more dramatic results those on GLP-1 agonists were significantly less likely to experience AUD recurrence