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Enhanced blood vessel formation could theoretically support tumor growth and spread

However, during increased electron flux, superoxide production may reach a critical threshold, which may allow trafficking of superoxide anions through the mitochondrial transition pore into the cytosol, in which further damage and/or the activation of additional ROS sources may occur

Individual factors including concentration used, baseline skin condition, age, lifestyle, and complementary skincare significantly affect benefit retention creating substantial variation in personal outcomes requiring experimentation for determining optimal individual approach

Nguyen, M.D., MBA, MPH, DTM&H, FAAD