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Semaglutide 24 mg once weekly in patients with non-alcoholic steatohepatitis-related cirrhosis: a randomised, placebo-controlled phase 2 trial
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[7] [8] This triple-receptor mechanism distinguishes it from existing approved agents such as semaglutide (a GLP-1 agonist) or tirzepatide (a dual GLP-1/GIP agonist)
Both medications share similar side effects, but research suggests important differences in tolerability
Most states require BMI of 27+ with at least one weight-related comorbidity (hypertension, dyslipidemia, sleep apnea, NAFLD) or BMI of 30+ without comorbidities
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