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This typically involves: Intrinsic factor antibodies (highly specific for pernicious anaemia, though sensitivity is only 50%) [12] [28] Gastric parietal cell antibodies (more sensitive but less specific) Coeliac serology if malabsorption is suspected Consideration of upper gastrointestinal endoscopy in selected cases, particularly with autoimmune gastritis/pernicious anaemia NICE guidance emphasises that treatment should not be delayed whilst awaiting antibody results if clinical features strongly suggest deficiency, as irreversible neurological damage can occur
The combined metabolic burden of both agents, particularly in the context of severe caloric restriction, could potentially affect: Reproductive hormone balance Glucose homeostasis Fluid and electrolyte balance Hypoglycaemia risk : For people with diabetes taking Wegovy alongside diabetes medications, there is an increased risk of hypoglycaemia
Changes in PMS Symptoms: Breast tenderness, cramps, and mood swings may be brought about Semaglutide to be more severe or milder in very few cases due to its regulating power over the hormones
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