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Abbreviations EX: Exenatide SEM: Semaglutide 5-Aza: 5-Azacytidine AMH: Anti-Mllerian hormone AR: Androgen receptor Ctrl: Control CpG: Cytosine-phosphate-guanine DHT: Dihydrotestosterone DNMT: DNA methyltransferase ELISA: Enzyme-linked immunosorbent assay Fer-1: Ferrostatin-1 GSH: Reduced glutathione GSSG: Oxidized glutathione GPX4: Glutathione peroxidase 4 H&E: Hematoxylin and eosin IF: Immunofluorescence IHC: Immunohistochemistry IR: Insulin resistance LCMS/MS: Liquid chromatographytandem mass spectrometry MDA: Malondialdehyde MSP: Methylation-specific polymerase chain reaction BSP: Bisulfite sequencing polymerase chain reaction PCOS: Polycystic ovary syndrome ROS: Reactive oxygen species References Carmina E, Longo RA (2023) Semaglutide treatment of excessive body weight in obese PCOS patients unresponsive to lifestyle programs

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Understanding these pathways reveals why this system represents such a promising target for metabolic health optimization

Excessive cardio can impair muscle retention and may be counterproductive for body composition goals