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Elevated free IGF-1 in epidemiological studies is associated with increased prostate, pre-menopausal breast, and colorectal cancer risk, though those associations involve chronically elevated endogenous IGF-1, not short-duration pharmaceutical use [8]

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As vitamin A is also required for biosynthesis of cone opsins, deficiency can also cause poor daytime vision, with cone dysfunction causing poor colour perception and loss of visual acuity (Sajovic et al, 2022)

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