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A clinical study involving 564 adults (BMI 30-40 kg/m2, without T2DM) found that compared with orlistat (3120 mg, weight loss of 4.1 kg), LIR (subcutaneous administration of 1.2 mg/d, 1.8 mg/d, 2.4 mg/d or 3 mg/d) had an average weight loss of 4.8-7.2 kg, the two-year extended experiment of which also showed similar results (88, 89)

An enzyme called dipeptidyl peptidase-4 (DPP-4) degrades it within two to three minutes, so its effects are brief and limited to the period right after eating

N Engl J Med 390(15):13941407 Petrie MC, Borlaug BA, Butler J, Davies MJ, Kitzman DW, Shah SJ et al (2024) Semaglutide and NT-proBNP in obesity-related HFpEF

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