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Natural products, especially monomers and compound preparations with immune-metabolic dual regulatory activities, have shown unique value in regulating this network, reversing pulmonary vascular remodeling, and improving right heart dysfunction by virtue of their advantages in multi-target synergistic intervention

We also created a GSH-insensitive control probe for validation studies

Second, cancer cells are highly adaptable and can activate compensatory antioxidant pathways, like the thioredoxin system, to survive GSH inhibition, reducing therapeutic effectiveness

PMID: 7883440 Anti-oncogene product p53 binds DNA helicase

& Muoz-Torres, M