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Your body makes small amounts of TUDCA naturally as part of the bile acid pool that helps you digest fats.8 Historically, TUDCA as a supplement has its roots in the use of bear bile in Traditional Chinese Medicine, where it has been used for thousands of years.12 Bear bile was valued for treating liver problems, fevers, inflammation, and eye conditions across China, Korea, and Japan.13 Because bear bile is naturally rich in UDCA and TUDCA compared with other animal sources, it was uniquely prized in these remedies.12 Today, TUDCA supplements typically no longer rely on animal sources

Radioligand and fluorescent binding assays, competition binding, recombinant receptor-expressing cell lines, functional readouts through a defined coupling pathway, and antagonist controls demonstrating that an effect is receptor-mediated

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