Growth hormone secretagogues demonstrate a bell-shaped dose-response curve, meaning that beyond a certain threshold, increasing the dose yields no additional benefit and may reduce receptor sensitivity. Smith et al., Peptides Taking too much Ipamorelin can lead to diminished returns , or worse, GH resistance , where your body adapts and no longer responds
Gastrointestinal Problems Some people have reported nausea, bloating, and abdominal pain after taking huge doses of glutathione
Parthasarathy, A., Borrego, E
Enzymes in your stomach and liver break down much of the glutathione before it enters the bloodstream
Those with significant fat loss goals Individuals with 50+ pounds to lose may benefit from extended protocols with strategic breaks rather than aggressive dosing