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The glucagonostatic characteristics of GLP-1 RA could prove to be more relevant to individuals with beta cell deficiency [51] which contrasts with type 2 diabetes where beta cell dysfunction and impaired incretin effect may dominate [52]
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A patient who is obese and diabetic may ultimately receive a different therapy than someone who is obese and hypertensive, or obese with rheumatoid arthritis, or obese with cognitive decline if we can design drugs that are turbo-charged to address these additional pharmacologies. Rounding up his presentation, DiMarchi encouraged the industry to also embrace observation
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Blanca AJ, Ruiz-Armenta MV, Zambrano S, Miguel-Carrasco JL, Arias JL, Arvalo M, Mate A, Aramburu O, Vzquez CM (2016) Inflammatory and fibrotic processes are involved in the cardiotoxic effect of sunitinib: protective role of L-carnitine
