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Multiple reviewers reported unexpected dose reductions or being prescribed the wrong medication entirely

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For example, a 2005 study found that NAC administration failed to raise glutathione levels in rats,36 and a 2022 study on mice suggested that it may promote the metastatic spread of certain cancers.37 While its true that animal studies don't directly translate to human outcomes, they're still important to consider when choosing a supplement meant to support your health and wellness

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Individuals with reduced DHFR activity are more likely to accumulate UMFA and may therefore benefit from using methylfolate or folinic acid instead of folic acid