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This narrative review examines the prospects for future non-insulin agents and therapeutic approaches in early development that aim to improve glycaemic control in type 2 diabetes
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In fact, reactive oxygen species (ROS) and peroxides (H2O2) upregulate the transsulfuration pathway (homocysteine towards cysteine and eventually the GSH-Px system) and downregulate the transmethylation (homocysteine towards methionine) (Figure 3)
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