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severe gastrointestinal adverse events may lead to dehydration and acute kidney injury

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The resulting NO sustained release system can controllably release NO at an average rate of 1.74 nmol L 1 h 1 for over 14 days, promoting endothelial cell growth, significantly improving wound angiogenesis and collagen deposition, and exhibiting anti-inflammatory effects, ultimately promoting diabetic wound healing

Full cycle (812 weeks): The compound builds up systemic benefit over the full cycle

D.SatylganovaA.et al (2020)