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Practical takeaway: Most human users report noticeable appetite suppression during the first 3-7 days of loading, consistent with the animal data showing rapid onset followed by tolerance

If patients are to start NASCOBAL before having tolerated cyanocobalamin parenterally, consider administering an intradermal test dose of parenteral vitamin B12 to patients suspected of cyanocobalamin hypersensitivity

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If weight management is your primary goal, Mounjaro (tirzepatide) or Wegovy (semaglutide 2.4 mg) are the licensed options

Consult with the pharmacy team if you have any questions or concerns about the storage or administration of semaglutide