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Thus GLP-1 was shown to regulate a number of diverse functions: reduction in digestive enzyme secretion, slowing of gastric motility, increases in heart rate and blood flow, increased bone remodeling, and suppression of appetite (via hypothalamic and brainstem nuclei)
Within the CNS, GLP-1R is most abundant in areas involved in the regulation of energy balance and metabolism (hypothalamus and brainstem), reward circuits (VTA, NAc), autonomic output (e.g., VMH and PVN), and neuroendocrine function
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