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Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: a randomised, double-blind, placebo and active-comparator-controlled, parallel-group, phase 2 trial

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Additional Considerations Common side effects seen with Wegovy may include: Nausea or vomiting Diarrhea or constipation Abdominal pain Headache Tiredness Contact your healthcare provider if you have any of the following side effects: Abdominal pain, nausea, or vomiting that does not go away

preserves physiologic feedback loops (somatostatin/IGF1 negative feedback)

If you go the cycling route, the off periods require aggressive lifestyle management