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This latter induced the formation of reactive oxygen species (ROS) in the hepatocytes resulting in the increase in cellular thiobarbituric acid reactive substances (TBARS) and glutathione (GSH) depletion
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Cyclophosphamide (CP) is a commonly used human or small animal anti-neoplastic agent
However, real-life analyses indicate a higher discontinuation rate, of approximately 70% stopping within 2 years, especially in non-diabetic patients (112, 113)
As the newest addition to incretin-based drugs, tirzepatide harbors the potential to counteract most of the pathogenetic mechanisms underpinning CKD in T2D displaying unprecedented features in terms of glucose and weight lowering, accompanied by promotion of insulin sensitivity, control of SBP, dyslipidemia, and biomarkers of inflammation and endothelial dysfunction
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