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The lack of clear genetic targets for these conditions has constrained the application of in vivo genome editing

To avoid a possible effect of food and water intake and physical activity, the meal plan and total daily fluid intake as well as physical activeness were kept constant during the study and the patients received a dietary advice with provided by a renal dietitian before the study commenced

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However, there is no overall impairment in long-term energy balance, similar to Glp1r Phox2b/ mice, which have similar body weight, adiposity, and long-term food intake to controls on either chow or HFD 127

So I would say this Q and A, we're gonna, we're gonna do quite a few rapid fire questions