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The first reaction is rate limiting and is catalyzed by the enzyme glutamate-cysteine ligase (GCL, EC 6.3.2.2
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Parenteral Gln supplementation combined with enteral nutrition increased plasma and tissue Gln concentrations by upregulating the expression of heat shock protein 90 (Hsp90) and attenuated apoptosis in the lymphoid organ spleen and circulating lymphocytes, ultimately enhancing immune function and improving survival in severely burned rats (36)
Microbiota-driven gutbrain signaling underlies antidepressant effects of a GLP-1 analog by Liang Bian, Yang Cai, Yuan Zhang, Ling Shen, Huijuan Wang, Feng Gao, Ningbo Cai, Wenbo Chen, Conghui You, Yurui Yang, Fang Wang, Yonggui Yuan, Bing Han, and Honghong Yao
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